In: Journal of Endocrinology , Vol. Yamanouchi K, Arai Y. Journal of Endocrinology. Yamanouchi, K. In: Journal of Endocrinology. AU - Arai, Y. PY - Y1 - N2 - Differentiation of sexual behavior patterns in male rats is dependent on the internal secretion of testes dur ing neonatal life.
RYAN, B. Anthropogenic estrogens are pervasive in the environment. Although the effects of these xenoestrogens are controversial in humans, some fish species are adversely affected in contaminated ecosystems. While studies investigating endocrine disruptors typically focus on reproductive physiology and fertility, exposure to estrogens during development can also alter sexual differentiation of the nervous system and behavior in rodents.
As a result, the brain can be imprinted such that it does not respond normally to estrogens in adulthood. Despite this, few studies have rigorously investigated the effect of developmental exposure to environmental estrogens on adult sexually dimorphic behavior in rats. Roberts, unpublished observation. In addition to facilitating lordosis, P facilitates proceptive behavior. Earlier studies have shown that, in the primate 67 but not the rodent 6 , 7 , 37 , LHRH may enhance proceptivity.
This is in contrast to the results from the current study. The reason will require further studies that specifically address the potential difference in observation. Precisely how the metabolism of LHRH and the role of the LHRH receptor fits into this complex sequence of events remains to be determined by mapping the spatial and temporal activation of cellular and intracellular structures.
The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Department of Defense or the Uniformed Services University of the Health Sciences. We thank Andrea Reyna for expert technical assistance in animal surgery and behavioral testing.
We also thank Drs. Richard Mills and Heather Fugger and Ms. Emily Baldwin for their editorial assistance, and Drs. Greg Mueller and Bill Driscoll for helpful discussions regarding peptide and enzyme chemistry. Moss RL , Cooper KJ Temporal relationship of spontaneous and coitus-induced release of luteinizing hormone in the normal cyclic rat.
Endocrinology 92 : — Google Scholar. Pfaff DW Luteinizing hormone-releasing factor potentiates lordosis behavior in hypophysectomized ovariectomized female rats.
Science : — Beach FA Locks and beagles. Am Psychol 24 : — Beach FA Sexual attractivity, proceptivity, and receptivity in female mammals. Horm Behav 7 : — Peptides 2 : — Pharmacol Biochem Behav 22 : — Neuroendocrinology 36 : — Horm Behav 48 : — Neuroendocrinology 41 : — Physiol Behav 57 : — Schiml PA , Rissman EF Effects of gonadotropin-releasing hormones, corticotropin-releasing hormone, and vasopressin on female sexual behavior. Horm Behav 37 : — Frontiers Neuroendocrinol 24 : 79 — Brain Res : — Physiol Behav 58 : — Ahlenius S Brain monoaminergic neurotransmission in the mediation of lordosis behavior in the female rat.
Neurosci Biobehav Rev 17 : 43 — Pharmacol Biochem Behav 13 : 81 — Pfaus JG , Gorzalka BB Selective activation of opioid receptors differentially affects lordosis behavior in female rats. Peptides 8 : — Endocrinology : — Fadem BH , Barfield RJ , Whalen RE Dose-response and time-response relationships between progesterone and the display of patterns of receptive and proceptive behavior in the female rat. Horm Behav 13 : 40 — Paxinos G , Watson C The rat brain in stereotaxic coordinates.
Orlando, FL : Academic Press. Antunes-Rodrigues J , McCann SM Water, sodium chloride, and food intake induced by injections of cholinergic and adrenergic drugs into the third ventricle of the rat brain. Proc Soc Exp Biol Med : — J Med Chem 35 : — J Pharmacol Exp Ther : 95 — Methods Neurosci 23 : — J Neuroendocrinol 9 : — Endocrinology : 45 — J Biol Chem : — Neuroendocrinology 52 : — Dudley CA , Lee Y , Moss RL Electrophysiological identification of a pathway from the septal area to the medial amygdala: sensitivity to estrogen and luteinizing hormone releasing hormone.
Synapse 6 : — Physiol Behav 50 : — Peptides 14 : — Biochem Biophys Res Commun : — Peptides 4 : 25 — Purification of the enzyme and determination of specificity with synthetic and natural peptides.
Eur J Biochem : 81 — Ann Rev Pharmacol Toxicol 22 : — Handbook of psychopharmacology: drugs, neurotransmitters and behavior. Vol New York : Plenum Publishing Corp.
Advis JP , Krause JE , McKelvy JF Luteinizing hormone-releasing hormone peptidase activities in the female rat: characterization by an assay based on high-performance liquid chromatography. Anal Biochem : 41 — Assessment by high-performance liquid chromatography. Neuroendocrinology 43 : — Sirinathsinghji DJ GnRH in the spinal subarachnoid space potentiates lordosis behavior in the female rat. Physiol Behav 31 : — J Neurosci Res 74 : — Soc Neurosci Abstract 14 : Gen Comp Endocrinol : — Reproduction : — Neuroendocrinology 58 : — Regul Pept 54 : — Gestrin ED , White RB , Fernald RD Second form of gonadotropin-releasing hormone in mouse: immunocytochemistry reveals hippocampal and periventricular distribution.
FEBS Lett : — Cell Mol Neurobiol 19 : — J Neuroendocrinol 15 : — J Clin Endocrinol Metab 88 : — Kauffman AS , Rissman EF A critical role for the evolutionarily conserved gonadotropin-releasing hormone II: mediation of energy status and female sexual behavior. Bourguignon JP , Alvarez-Gonzalez ML , Gerard A , Franchimont P Gonadotropin-releasing hormone inhibitory autofeedback by subproducts antagonist at N- methyl-D aspartate receptors: a model of autocrine regulation of peptide secretion.
Physiol Behav 52 : — Acta Endocrinol : — MacDonald MC , Wilkerson M Peripubertal treatment with N- methyl- d -aspartic acid or neonatally with monosodium glutamate accelerates sexual maturation in female rats, an effect reversed by MK Horm Behav 31 : — Oxford University Press is a department of the University of Oxford.
0コメント